Follow this innovation
[ via 
] [?]
Chemical synthesis and antitumor activity of FR901464 and its analogs
University of Pittsburgh
posted on 02/22/2010
Pitt Researchers Create Anticancer Molecule 10- to 100-times More Powerful Than Leading Treatment.
Suggested Uses
- Cancer chemotherapeutics
- Potential new therapeutic targests for cancer
Advantages
- High antitumor activity, more potent than paclitaxol
- More concise total synthesis of FR901464 than those reported in the literature
- Exhibits antitumor activity at low concentrations (0.056-0.18 mg/kg)
Detailed Description
Investigators have discovered a unique total chemical synthesis of FR901464 and its analog. While the IC50 of FR901464 was known to be 1 nM against breast cancer cells (MCF-7 cells), it was discovered that this novel synthetic analog was far more potent than FR901464 against these cells.
The inventors believe that these compounds inhibit RNA splicing and can also be used in diseases in which this is evident.
Lead Innovator
Kazunori Koide, PhD
Department of Chemistry
File Number: 1313
Disease: Cancer
| Patent Number(s): | 2008/0096879 |
|---|
This innovation currently is not available for online licensing. Please contact Alexander Ducruet at University of Pittsburgh for more information.
request more info
ProfileFind more innovations
