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Use of tolerogenic dendritic cells for enhancing tolerogenicity in a host and methods for making these
University of Pittsburgh
posted on 06/29/2009
The invention is a method for regulating the immune response wherein tolerogenic dentritic cells (DCs) are introduced into the body.
Suggested Uses
- Enhance tolerance
- Useful for prolonging foreign graft survival and for ameliorating inflammatory-related diseases, such as autoimmune diseases, including autoimmune arthritis, autoimmune diabetes, asthma, septic shock, lung fibrosis, glomerulonephritis, artherosclerosis, as well as AIDS.
Detailed Description
The tolerogenic dentritic cells are obtained by harvesting dentritic cells from a mammalian donor and treating the cells with an oligodeoxyribonucleotide (ODN) which binds to nuclear factor .kappa.B (NF-.kappa.B). The tolerogenic dentritic cells are useful for prolonging graft survival in a mammalian host and for inhibiting the inflammatory response. The present invention also relates to tolerogenic DCs comprising a viral vector wherein the DCs maintain a tolerogenic state in the presence of the viral vector.
File Number: 366
Disease: Autoimmune and Inflammation
| Patent Number(s): | 6936468 |
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This innovation currently is not available for online licensing. Please contact Michelle A. Booden at University of Pittsburgh for more information.
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