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Dissolvable Microneedle Arrays for Effective Transdermal Delivery
University of Pittsburgh
posted on 01/04/2010
Innovators have developed a novel technology for direct micromilling of microneedle arrays from carboxymethyl cellulose (CMC) sheets that increases the precision, reproducibility, and versatility of the fabrication process.
Suggested Uses
- Drug delivery patches.
- Simultaneous delivery of optimal quantities of combinations of antigens and/or adjuvant.
Advantages
- Fabrication processes are flexible and enable simple and rapid low cost production with efficient scale-up potential
- Allows for construction of more complex mastermold features than can conventional lithography and laser etching processes
- Increases speed and precision of drug delivery
Detailed Description
Investigators at the University of Pittsburgh devised methods for fabricating dissolvable microneedle arrays using master molds formed by micromilling techniques. The investigators have successfully molded solid microneedles using various biodegradable materials that are compatible with sensitive biologics, peptides, proteins, nucleic acids, and other various bioactive components.
The accuracy of this milling technique increases reproducibility, structural and mechanical integrity of the microneedles among different production patches.
The investigators have shown uniform drug delivery using these microneedle arrays in mouse models.
File Number: 2006
Other Information:
Background
Transdermal delivery of biologics using microneedle array based devices offers attractive advantages over prevailing oral and needle-based drug delivery methods. Unfortunately the current method of making and testing microneedles has several flaws. A microneedle array which provides efficient, precise, and reproducible delivery of biologically active molecules to human skin is desperately needed.
This innovation currently is not available for online licensing. Please contact Michelle A. Booden at University of Pittsburgh for more information.
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