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Lymph Nodes as Sites for Tissue Regeneration
University of Pittsburgh
posted on 06/30/2009
The inventors demonstrate the use of lymph nodes as a new site for liver regeneration.
Suggested Uses
- Extra-hepatic tissue for liver diseases
- Insulin producing tissue for diabetes
- Other bioengineered tissue for the production of missing proteins
Advantages
- No currently available technology for lymph node engraftment described in literature
Detailed Description
This study demonstrates that the hepatocytes transplanted intraperitoneally can engraft and survive in lymph nodes, and rescue an animal model of metabolic liver disease. The intraperitoneal transplantation of
hepatocytes could be an efficient mode of lymphatic site transplantation, generating a functional extra-hepatic liver mass for patients affected with liver disease.
File Number: 1664
| Patent Number(s): | WO/2009/111778 |
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This innovation currently is not available for online licensing. Please contact Alexander Ducruet at University of Pittsburgh for more information.
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