Method for treatment of drug-resistant HIV-1

University of Pittsburgh
posted on 12/18/2009

Investigators at Pitt have identified a lead class of compounds that retain potent activity against many drug-resistant variants of HIV-1.

Suggested Uses

Treatment of HIV-1 infection
Treatment of drug-resistant HIV-1

Advantages

Active against several drug resistant strains of HIV-1 which include HIV-1 with the drug-resistance mutations K65R, L74V or M184V
Active against all strains of HIV-1 that are resistant to AZT

Innovation Details

Detailed Description

The compounds are 3’azido-2’,3’dideoxy purine nucleosides or phosphonates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives. In particular, the compounds show potent antiviral activity against HIV 1 resistance mutants including HIV 1K65R, HTV 1K70E, HIV 1L74V, HIV 1M184V, HIV 1Q151M and inhibitory activity against HIV 1 RT harboring TAMS or insertion mutations including HIV 1AZT3, HIV 1AZT7, HIV 1AZT9, HIV 1Q151M, or HIV 169insertion.