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Normalization of Time Domain-Optical Coherence Tomography (TD-OCT) Retinal Nerve Fiber Layer Thickness Measurements
University of Pittsburgh
posted on 01/14/2010
The goal of this invention is to normalize the Retinal Nerve Fiber Layer (RNFL) thickness measurements of off-centered TD-OCT circle scans to a universal (virtual) location centered on the Optic Nerve Head (ONH) of the same eye.
Suggested Uses
- Allows clinicians to track, compare and detect retinal changes over a longer period of time.
Advantages
- RNFL thickness measurement normalization of off-centered TD-OCT circle scans to a universal(virtual) location centered on the ONH.
- Mathematical model of the retinal tissue pattern by using 3D SD-OCT volume.
- Improved Reproducibility of TD-OCT scan.
Detailed Description
Both a mathematical model of the retinal tissue pattern and a scan location matching (SLM) algorithm. (ID01633, PCT/US2009/052951) are used for this calculation. Using the normalized RNFL thickness measurements avoids the previous downfall of RNFL thickness measurement variability. This makes it possible for clinicians to track, compare, and detect any retinal changes over a longer period of time (independent of imaging modality i.e. TD-OCTor SD-OCT).
There is currently no technology /methodology to provide backward compatibility between two-dimensional (2D) TD-OCT scans and three dimensional (3D) SD-OCT volumetric data.
File Number: 2065
Disease: Ophthalmology and Optometry
Other Information:
Stage of Development
Algorithm successfully tested on 12 healthy eyes from 12 healthy subjects from UPMC Eye Center.
This innovation currently is not available for online licensing. Please contact Brian Copple at University of Pittsburgh for more information.
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