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Materials and Methods for Improving the Biocompatibility of Implantable Medical Devices by Enhancing Device Permeability to Water and Molecules
University of Utah Technology Commercialization Office
posted on 01/16/2012
Invention Summary
Simple redesign of existing implantable medical devices to improve the biocompatibility and reduce the foreign body response (FBR).
Features/Benefits
·
· Example of test results in vivo
o Inflammation and reactive astrogliosis around an untreated and treated medical device
§ Untreated Device: (Panel A) The cortical brain tissue reaction to the untreated device was characterized by the presence of CD68+ macrophages adjacent to and filling the implantation tract.
§ Treated Device: (Panel B) In contrast, for the treated device, the distribution of CD68+ immunoreactivity was reduced, with sporadic clusters of CD68+ immunoreactivity symmetrically distributed around the device.
Technology
Opportunity A patent application
(PCT/US2012/025589) was filed with the U.S. Patent and Trademark Office on the
design and method of use. The
invention is available for licensing under either exclusive or non-exclusive
terms.
Inventors
Dr. Patrick Tresco, Professor, Department of Bioegineering
Contact
James Thompson
University of Utah
Phone: (801)581-7792
Direct: (801)213-3564
james.thompson@tco.utah.edu
]]>File Number: U-4690
This innovation currently is not available for online licensing. Please contact Kurt Sturm at University of Utah Technology Commercialization Office for more information.
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