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Pharmacokinetics of Highly Fluorinated Amino Acids
University of Utah Technology Commercialization Office
posted on 01/16/2012
Unique Fluorinated Amino Acids
University Reference Number: U-4063 and U-4109
Invention Summary
Novel and unique highly fluorinated beta amino acids and trifluorothreonine & analogs.
Features/Benefits
· Fluorinated beta amino acids and trifluorothreonine may be used to:
§ Enhance membrane permeability (including the blood brain barrier)
§ Increased stability of peptides
§ Prolong in vivo half life of peptides
§ Investigate conformation and metabolism of host peptides or proteins by 19F NMR
Technology Opportunity
US patent 8,052,961 covers the composition of matter and synthesis of highly fluorinated beta amino acids. A U.S. patent application (U.S. Serial No. 12/439,320) was filed with the U.S. Patent and Trademark Office on 2/27/09 on the composition of matter and synthesis of trifluorothreonine compounds. The invention is available for licensing under either exclusive or non-exclusive terms.
Inventors
Dr. Yihua Bruce Yu
Contact
James Thompson
University of Utah
Phone: (801)581-7792
Direct: (801)213-3564
File Number: U-4109
This innovation currently is not available for online licensing. Please contact Kurt Sturm at University of Utah Technology Commercialization Office for more information.
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