Encoded Molecular Sieve Particles in a Thin Film Fiber Optic Electrode Sensor Apparatus for Concurrent Viewing and Chemical Sensing of Sample

University of Texas at Dallas
posted on 07/02/2011

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Researchers at the University of Texas at Dallas have also developed a new high-throughput screening molecular sieve particle, which can be synthesized in a variety of shapes and morphologies. Different chemical functionalities are encoded on separate shaped molecular sieve particles and populations of these encoded particles can be distributed in an etched optical fiber bundle thus resulting in a single sensor array carrying thousands of chemistries. This system offers a cost effective, flexible, and efficient chemical analysis method comprising encoded molecular sieve particles in an optical sensor analytical system to encode and identify chemical functionalities.

Background

The use of fluorescence/luminescence microscopy has been driven by the ability to define the temporal and spatial interplay of samples in a variety of environments. Fluorescence imaging is one of the most valuable methods for analyzing microenvironments, particularly cellular microenvironments, and can be expected to find broader applicability as the rapidly growing computer and video industries provide new tools/hardware for fluorescence imaging. It is challenging to develop novel techniques and methodologies in this field because there are limited number of analytes that are amenable to luminescence imaging. These patented technologies, developed at the University of Texas at Dallas, expand the applicability of remote luminescence imaging techniques offering significant improvements in the ability to study fundamental cellular properties.

Potential Benefits

Thin Film Fiber Optic Electrode Sensor

·         Broad sample size: Increases the types and number of samples amenable to remote luminescence imaging

·         Fluorescent and Electrochemical sensor: Combining viewing and chemical sensing with imaging fiber chemical sensors offers a significant advance in studying fundamental properties on a cellular level.

·         Remote analysis: Optical imaging sensors can provide images and chemical information from remote hard-to-reach locations and hostile environments.

Molecular Sieve Particles

·       Selectivity:  Greater selectivity based on molecular sieve's macroscopic geometric shapes and their molecular-sized pore diameters.

·         Increased encoding capabilities: The plurality of molecular sieve microscopic geometric shapes results in a five-fold enhancement in tunable parameters and an increase in encoding possibilities.

·         Particle Diversity:  Can be synthesized with higher atomic weight atoms such as Aluminum and transitional metals permitting a variety of new and alternative methods

Potential Applications

·Applicable to any microenvironment in which fine spatial resolution of imaging concurrent with chemical sensing is needed.

·Ideal for imaging the morphology and chemistry from single biological cells and tissue.

·Measuring chemical concentrations at cell surfaces on scales smaller than a single cell.

·Encoding and identification of chemical functionalities across a wide variety of industries including life sciences, pharmaceuticals, agriculture, foods, chemical, and petrochemicals

Published Works

• S.S. Khan, E.S. Jin, N. Sojic and P. Pantano,* A Fluorescence-Based Imaging Fiber Electrode Chemical Sensor for Hydrogen Peroxide, Analytica Chimica Acta 404, 213-221 (2000).

• E.S. Jin, B.J. Norris and P. Pantano,* An Electrogenerated Chemiluminescence Imaging Fiber Electrode Chemical Sensor for NADH, Electroanalysis 13, 1287-1290 (2001).

• Paul Pantano, Claudia C. Meek, Jing Wang, Decio H. Coutinho and Kenneth J. Balkus, Jr., Optical encoding with shaped DAM-1 molecular sieve particles, Lab Chip, 3, 132-135 (2003)

IP Status

·         US Patent 6,487,326 Issued 11/26/2002, titled "Thin film fiber optic electrode sensor array and apparatus"

·         US Patent 6,790,672 B2 Issued 9/14/2004, titled "Encoded Molecular Sieve Particle-Based Sensors"

Inventors

US Patent 6,487,326

·         Paul Pantano

·         Eunsook S. Jin

·         Samina S. Khan

·         Harold W. Stokes

 US Patent 6,790,672 B2

·         Kenneth Balkus

·         Paul Pantano

·         Meek, Claudia C.

·         Coutinho, Decio H.

Licensing Opportunity

This technology is available for exclusive or non-exclusive licensing.

Imaging fiber arrays in combination with epi-fluorescence/CCD camera imaging system

Case ID:  MP-09-0055M

Contact: Becky Stoughton, email: rebecca.stoughton@utdallas.edu, phone: 972-883-4574