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The Human Serotonin Transporter Gene (SLC6A4) is a Susceptibility Locus for Autism, Harbors Heterogeneous Functionally-Abnormal Alleles, and Confers Genetic Risk for Autism Spectrum Disorders in a Male-Biased Fashion
Vanderbilt University
posted on 01/25/2010
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Detailed Description
Autism spectrum disorders are common and are reported to have a population prevalence of ~1/300- 1/500. The Sutcliffe laboratory, in collaboration with the Blakely laboratory, has identifi ed the serotonin transporter gene (gene symbol: SLC6A4; protein: hSERT) as being a genetic risk locus for autism and autism spectrum disorders. This would represent the first autism gene to be described in which functionally abnormal alleles confer genetic risk for this common developmental disorder. Based on our current findings, this gene appears to confer risk that affects a signifi cant number of families with autism and related traits.
Supplemental Documents
VU0561—Allelic Variation in the Serotonin Transporter as an Indicator of Autism
Inventors
Randy Blakely
Nicholas Campbell
Ryan Delahanty
Tammy Jessen
Harish Prasad
James Sutcliffe
Jeremy Veenstra-Vander Weele
Chong-Bin Zhu
CONTACT
Karen Rufus
(615) 322-4295
karen.rufus@vanderbilt.edu
File Number: MKT0561
This innovation currently is not available for online licensing. Please contact Karen Rufus at Vanderbilt University for more information.
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