The invention relates to the analysis of blood analytes using a device inserted into the bloodstream. This device comprises a housing suitable for disposition in a subject’s bloodstream, a probe comprising a support coupled to the housing, and a binding agent coupled to the support. The housing can be a hypodermic needle or syringe or a catheter. The probe of the device may contain a support coupled to the housing such as a stent, a filter, a chip or a membrane, or the support may be a polymer, a resin, glass, or a porous material. The probe may comprise a support and binding agent and may be positioned inside or outside of the housing. The binding agent may be located on or in the support and may exhibit affinity for a component or components present in blood. For example, the binding agent may be a peptide, a polypeptide such as an antibody or receptor, a drug, a nucleic acid, a lipid, a glycolipid, a carbohydrate, a toxin, an antigen, a hapten or an enzyme substrate. The primary aspect of the invention is for sampling body fluids, e.g., blood for analytes using a device inserted into the bloodstream, particularly useful for sampling of less abundant or rare blood analytes.

Inventors
Richard Caprioli


CONTACT
Karen Rufus
(615) 322-4295
karen.rufus@vanderbilt.edu

File Number: MKT0602