Antibodies to NGAL for Detection of Cancer and Kidney Damage

Neutrophil gelatinase-associated lipocalin (NGAL) is a recently discovered cytokine. Because many types of cells produce NGAL in response to injury, it provides a biomarker for several chronic conditions. NGAL can be used in a diagnostic assay to detect certain types of cancer cells (see WARF reference number P95225US). It serves as a strong indicator of kidney damage, and may be useful to monitor other chronic conditions as well.

UW-Madison researchers have developed purified antibodies to NGAL. These unique antibodies can be used in immunoassays for the diagnosis and prognosis of some types of cancer, renal failure and other diseases.
 

File Number: P09185US 

Other Information:
Stoesz S.P., Friedl A., Haag J.D., Lindstrom M.J., Clark G.M., and Gould M.N. 1998. Heterogeneous Expression of the Lipocalin N-gal in Primary Breast Cancers. Int. J. Cancer 79, 565-572.

See WARF reference number P95225US for an assay that uses these antibodies to detect some types of cancer cells.