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Improved contrast agent for MRI using fluorinated nanoparticles
Washington University in St. Louis
posted on 01/15/2007
Washington University is actively seeking partners to further develop an innovative new contrast agent for magnetic resonsnace imaging that could revolutionize diagnostic imaging. The agent, which uses fluorinated nanoparticles, enhances the use of MRI for diagnosing cardiovascular disease. Because the body does not naturally contain large amounts of fluorine, the background “noise” is eliminated and highly accurate images are produced rapidly. The nanoparticles adhere to fibrin clots in the arteries enabling precise detection of blockages and plaques. In contrast to alternative more invasive diagnostic methods, this non-radioactive agent is injected intravenously. Worldwide there are over 60 million MRI investigations each year, of which a significant proportion could utilize this new contrast agent.
Suggested Uses
Injectable contrast agent for two- and three-dimensional visualization of
- coronary artery disease
- vascular disease
- cerebrovascular disease
A superior substitute for typical gadolinium contrast agents
Advantages
- Non-radioactive, unlike x-ray diagnosis; fewer risks and handling issues
- Non-invasive: no catheter insertion means less patient discomfort and risk
- Greater accuracy: Superior resolution in images compared to current MRI contrast agent for greater physician and client satisfaction
- Rapid imaging of small blood vessels at normal magnetic field strengths for greater efficiency of MRI use
Detailed Description
This invention provides a new and improved method for enhanced magnetic resonance imaging for the cardiovascular system using fluorinated nanoparticles. It is a nontargeted contrast agent for medical imaging of the blood vessels in an interior portion of the body. The invention involves a unique fluorinated nanoparticle emulsion with a distinctive magnetic resonance signature to be detected by the magnetic imaging machine. Performance is improved by appropriate selection of MRI techniques and appropriate selection of resonance frequency coils.
File Number: improved_contrast_agent_for_mri_using_fluorinated_nanoparticl
Other Information:
State of Development
Tests carried out on live rabbits and on human carotid tissue.
| Patent Number(s): | 2006/0239919 |
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This innovation currently is not available for online licensing. Please contact Bradley J. Castanho at Washington University in St. Louis for more information.
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